Нейропилин 1

Нейропилин 1
Доступные структуры PDB Поиск ортологов: PDBe RCSB Список идентификаторов PDB 1KEX, 2QQI, 2QQM, 2QQN, 3I97, 4DEQ, 4RN5, 5C7G
Идентификаторы
Символы	NRP1, BDCA4, CD304, NP1, NRP, VEGF165R, Neuropilin 1
Внешние IDs	OMIM: 602069 MGI: 106206 HomoloGene: 2876 GeneCards: 8829
Связанные наследственные заболевания
Название болезнии		Ссылки
Тетрада Фалло		[1]
Генная онтология Функции • heparin binding • vascular endothelial growth factor binding • cytokine binding • semaphorin receptor activity • coreceptor activity • связывание с ионом металла • vascular endothelial growth factor-activated receptor activity • growth factor binding • связывание с белками плазмы • GTPase activator activity • protein kinase binding Компонент клетки • цитозоль • мембрана • внеклеточная область • semaphorin receptor complex • поверхность клетки • sorting endosome • часть мембраны • Конус роста • receptor complex • клеточная мембрана • аксон • neuronal cell body • early endosome • нейрофиламент • cytoplasmic vesicle • внеклеточное пространство • Фокальные контакты • neuron projection • glutamatergic synapse • integral component of postsynaptic membrane Биологический процесс • negative regulation of neuron apoptotic process • facioacoustic ganglion development • vascular endothelial growth factor signaling pathway • VEGF-activated neuropilin signaling pathway involved in axon guidance • toxin transport • cell migration involved in sprouting angiogenesis • semaphorin-plexin signaling pathway involved in axon guidance • positive regulation of retinal ganglion cell axon guidance • positive regulation of smooth muscle cell migration • sympathetic neuron projection guidance • vascular endothelial growth factor receptor signaling pathway • sensory neuron axon guidance • Ангиогенез • positive regulation of ERK1 and ERK2 cascade • animal organ morphogenesis • protein localization to early endosome • trigeminal nerve structural organization • regulation of axon extension involved in axon guidance • coronary artery morphogenesis • negative regulation of extrinsic apoptotic signaling pathway • neuron development • trigeminal nerve morphogenesis • angiogenesis involved in coronary vascular morphogenesis • commissural neuron axon guidance • negative regulation of axon extension involved in axon guidance • развитие сердца • response to wounding • artery morphogenesis • positive regulation of peptidyl-tyrosine phosphorylation • branching involved in blood vessel morphogenesis • platelet-derived growth factor receptor signaling pathway • positive chemotaxis • facial nerve structural organization • hepatocyte growth factor receptor signaling pathway • axonal fasciculation • retina vasculature morphogenesis in camera-type eye • dorsal root ganglion morphogenesis • axon extension involved in axon guidance • sympathetic ganglion development • Дифференцировка клеток • semaphorin-plexin signaling pathway involved in neuron projection guidance • cellular response to hepatocyte growth factor stimulus • dendrite development • sprouting angiogenesis • neuron migration • nervous system development • regulation of retinal ganglion cell axon guidance • branchiomotor neuron axon guidance • gonadotrophin-releasing hormone neuronal migration to the hypothalamus • negative regulation of axon extension • retinal ganglion cell axon guidance • renal artery morphogenesis • ventral trunk neural crest cell migration • positive regulation of endothelial cell proliferation • sympathetic nervous system development • endothelial tip cell fate specification • передача сигнала между клетками • regulation of vesicle-mediated transport • trigeminal ganglion development • positive regulation of cytokine activity • positive regulation of axon extension involved in axon guidance • Аксональное наведение • vestibulocochlear nerve structural organization • multicellular organism development • neural crest cell migration involved in autonomic nervous system development • endothelial cell chemotaxis • axonogenesis involved in innervation • dichotomous subdivision of terminal units involved in salivary gland branching • cellular response to vascular endothelial growth factor stimulus • motor neuron axon guidance • nerve development • миграция клеток • sympathetic neuron projection extension • semaphorin-plexin signaling pathway • передача сигнала • otic placode development • motor neuron migration • outflow tract septum morphogenesis • substrate-dependent cell migration, cell extension • integrin-mediated signaling pathway • positive regulation of endothelial cell migration • actin cytoskeleton reorganization • regulation of Cdc42 protein signal transduction • substrate adhesion-dependent cell spreading • neuropilin signaling pathway • VEGF-activated neuropilin signaling pathway • positive regulation of phosphorylation • endothelial cell migration • positive regulation of GTPase activity • positive regulation of angiogenesis • positive regulation of filopodium assembly • positive regulation of stress fiber assembly • positive regulation of focal adhesion assembly • positive regulation of cell migration involved in sprouting angiogenesis • positive regulation of substrate adhesion-dependent cell spreading • positive regulation of actin cytoskeleton reorganization • postsynapse organization • basal dendrite development • basal dendrite arborization Источники:Amigo / QuickGO
Профиль экспрессии РНК
Больше информации
Ортологи
Виды	Человек	Мышь
Entrez	8829	18186
Ensembl	ENSG00000099250	ENSMUSG00000025810
UniProt	O14786	P97333
RefSeq (мРНК)	NM_001024628 NM_001024629 NM_001244972 NM_001244973 NM_003873 NM_001330068	NM_008737 NM_001358959 NM_001358960
RefSeq (белок)	NP_001019799 NP_001019800 NP_001231901 NP_001231902 NP_001316997 NP_003864	NP_032763 NP_001345888 NP_001345889
Локус (UCSC)	Chr 10: 33.18 – 33.34 Mb	Chr 8: 128.36 – 128.5 Mb
Поиск PubMed	[2]	[3]
Викиданные
Просмотр/Править (Человек)		Просмотр/Править (Мышь)

Нейропилин 1 (англ. Neuropilin 1, NRP1; CD304) — мембранный белок, экспрессирован в нейронах, продукт гена NRP1. Один из двух нейропилинов человека.

Функции

Нейропилин 1 является мембрано-связанным ко-рецептором тирозинкиназного рецептора факторов роста эндотелия сосудов (VEGF) и семафоринов. Играет роль в VEGF-индуцированном ангиогенезе, направлении роста аксона, выживании, миграции и прорастании клеток.

Взаимодействия

Нейропилин 1 связывается с VEGF-A, VEGF-B, семафорином 3A.

См. также

• Нейропилин 2