Толл-подобный рецептор 2

Толл-подобный рецептор 2
1FYW
Доступные структуры PDB Поиск ортологов: PDBe, RCSB Список идентификаторов PDB 1FYW, 1FYX, 1O77, 2Z7X, 2Z80
Идентификаторы
Символ	TLR2 ; CD282; TIL4
Внешние ID	OMIM: 603028 MGI: 1346060 HomoloGene: 20695 ChEMBL: 4163 GeneCards: TLR2 Gene
Генная онтология Функция • lipopolysaccharide receptor activity • receptor activity • transmembrane signaling receptor activity • protein binding • signaling pattern recognition receptor activity • triacyl lipopeptide binding • diacyl lipopeptide binding • peptidoglycan binding • protein heterodimerization activity • lipoteichoic acid binding Компонент клетки • cytoplasm • plasma membrane • integral component of plasma membrane • external side of plasma membrane • cell surface • Toll-like receptor 1-Toll-like receptor 2 protein complex • Toll-like receptor 2-Toll-like receptor 6 protein complex • cell projection • cell body Биологический процесс • response to hypoxia • toll-like receptor signaling pathway • response to molecule of fungal origin • microglial cell activation involved in immune response • positive regulation of leukocyte migration • cell surface pattern recognition receptor signaling pathway • MyD88-dependent toll-like receptor signaling pathway • leukotriene metabolic process • apoptotic process • inflammatory response • immune response • signal transduction • I-kappaB phosphorylation • negative regulation of cell proliferation • response to toxic substance • positive regulation of Wnt signaling pathway • lipopolysaccharide-mediated signaling pathway • central nervous system myelin formation • response to progesterone • negative regulation of interleukin-12 production • negative regulation of interleukin-17 production • positive regulation of chemokine production • positive regulation of interferon-beta production • positive regulation of interleukin-10 production • positive regulation of interleukin-12 production • positive regulation of interleukin-18 production • positive regulation of interleukin-6 production • positive regulation of interleukin-8 production • positive regulation of tumor necrosis factor production • response to insulin • positive regulation of toll-like receptor signaling pathway • toll-like receptor 2 signaling pathway • toll-like receptor 4 signaling pathway • toll-like receptor TLR1:TLR2 signaling pathway • toll-like receptor TLR6:TLR2 signaling pathway • positive regulation of NF-kappaB import into nucleus • detection of triacyl bacterial lipopeptide • detection of diacyl bacterial lipopeptide • positive regulation of tumor necrosis factor biosynthetic process • chloramphenicol transport • negative regulation of growth of symbiont in host • innate immune response • positive regulation of nitric oxide biosynthetic process • positive regulation of transcription from RNA polymerase II promoter • nitric oxide metabolic process • positive regulation of oligodendrocyte differentiation • positive regulation of cytokine secretion • positive regulation of inflammatory response • defense response to Gram-positive bacterium • positive regulation of NF-kappaB transcription factor activity • positive regulation of nitric-oxide synthase biosynthetic process • pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response • induction by symbiont of defense-related host nitric oxide production • positive regulation of macrophage cytokine production • response to fatty acid • cellular response to bacterial lipopeptide • cellular response to lipoteichoic acid • cellular response to peptidoglycan • cellular response to diacyl bacterial lipopeptide • cellular response to triacyl bacterial lipopeptide Источники: Amigo / QuickGO
Профиль экспрессии РНК
Больше информации
Ортологи
Вид	Человек	Мышь
Entrez	7097	24088
Ensembl	ENSG00000137462	ENSMUSG00000027995
UniProt	O60603	Q9QUN7
RefSeq (мРНК)	NM_003264	NM_011905
RefSeq (белок)	NP_003255	NP_036035
Локус (UCSC)	Chr 4: 154.62 – 154.63 Mb	Chr 3: 83.84 – 83.84 Mb
Поиск в PubMed	[1]	[2]

TLR2 (толл-подобный рецептор 2, CD282) — мембранный белок, входящий в группу толл-подобных рецепторов, обеспечивающих функционирование врождённого иммунитета. TLR2 так же как TLR1 распознаёт патоген-связанные молекулярные структуры грам-положительных бактерий, включая пептидогликаны, липотейхоевую кислоту, некоторые компоненты микобактерий и зимозан клеточной стенки дрожжей.

Структура и функции

Библиография

• Tapping R.I., Omueti K.O., Johnson C.M. Genetic polymorphisms within the human Toll-like receptor 2 subfamily (англ.) // Biochem. Soc. Trans. : journal. — 2007. — December (vol. 35, no. Pt 6). — P. 1445—1448. — DOI:10.1042/BST0351445. — PMID 18031242.